Osteoarthritis is more than wear and tear. An Advanced Science study in mice and human synovium finds that HMGCR, the statin-targeted enzyme of cholesterol synthesis, runs too hot in synovial fibroblasts, overproduces cholesterol, drives cellular senescence, and fuels synovitis and cartilage breakdown; local joint knockdown of HMGCR in mice reverses senescence and eases pain and cartilage loss.
Resveratrol, rapamycin, and diet all claim to fight aging, so why do the effects vary so much? Studies in 2026 show anti-aging interventions succeed or fail depending on sex, life stage, and genetic background, pushing geroscience from a lifespan race toward hallmark-informed prioritization.
Senescent cells pile up because aging immune systems stop clearing them efficiently. Instead of killing every senescent cell, new 2026 reviews argue for senomorphic strategies that quiet SASP-driven inflammation.
Senescent cells have been the bad neighbor of aging biology for nearly two decades. Three 2026 papers flip the question: before we rush to clear them, do we even know what they are? Turns out we barely did — and now that we're learning, the picture is far less black and white.
A blue pill that might protect your brain, and a fiber classification system that's been misleading you for decades. Two stories about how oversimplified categories can steer us wrong.
You took NMN for three months and still look the same in the mirror. Why? Three landmark studies piece together how NAD⁺ collapses with age: how cells fake hypoxia, who eats your supplements, and whether topping NAD⁺ back up can truly rejuvenate old cells.