A decision model's probability is not how sure it is. On 77 PubMed papers, see how to check calibration and set a threshold from coverage and accuracy.

Why do senescent cells persist as organisms grow older? A 2026 Nature Aging study shows that declining chaperone-mediated autophagy (CMA) alters the senescent secretome and blunts macrophage engulfment via SIRPα and CD47 signaling. While pharmacological CMA activation reduced senescent cell burden and fibrosis severity in mice, the findings remain strictly preclinical.

A decision model reads the logits of listed options after one forward pass and turns them into probabilities. Jev discloses RLCD but not its loss; open replicas publish their heads.

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