Letting Agents Assign Tasks to Each Other: A Practical Build from tmux to Handoff
How to turn manual copy-pasting across CLI agent terminals into auditable mutual task assignment using dynamic discovery, capacity allocation, and file-first handoffs.
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One Month of Local Model Benchmarking: I Overturned My Own Rankings
From acceleration knobs and extreme quantization to a nine-model comparison, a large-sample retest at month's end reshuffled the entire leaderboard. A record of a broken yardstick, small-sample error bars, and the current division of labor between pi and local models.
Cholesterol Is Quietly Aging Your Joints: How a Statin Target Accelerates Osteoarthritis
Osteoarthritis is more than wear and tear. An Advanced Science study in mice and human synovium finds that HMGCR, the statin-targeted enzyme of cholesterol synthesis, runs too hot in synovial fibroblasts, overproduces cholesterol, drives cellular senescence, and fuels synovitis and cartilage breakdown; local joint knockdown of HMGCR in mice reverses senescence and eases pain and cartilage loss.
Fuel for Your Follicles: How an Injury-Triggered Metabolic Relay Wakes Sleeping Hair Stem Cells
Subcutaneous fat is more than a storage tank. In a Cell Metabolism mouse study, skin injury prompts macrophages to make fat cells release fatty acids; hair follicle stem cells take up these monounsaturated fatty acids via CD36, switch on Pgc1-alpha for energy, and exit dormancy to regrow hair, forming a macrophage-to-adipocyte-to-follicle metabolic relay.
One Forest Molecule, Three Fires: How Antroquinonol Calms an IgA Nephropathy Kidney
IgA nephropathy is the most common primary glomerulonephritis worldwide. In a mouse study, antroquinonol, a purified compound from Antrodia camphorata mycelium, switched three pathways at once, activating Nrf2, restraining T cells, and silencing the NLRP3 inflammasome, easing kidney damage.
A Desert Shrub That Makes Breast Cancer Cells Grow Old and Jam Their Own Recycling
## Against the hardest breast cancer, a desert shrub hits two brakes at once If you have heard that breast cancer can be treated by "reading its hormone recept