25 Experts Reviewed Every NAD+ Clinical Trial. Their Verdict? Six Words.
You've been taking NMN for six months. Did it actually do anything? A massive Nature Aging review finally has an answer: promising, but not magic.
Open →NAD+ Supplements: Can NMN Actually Reverse Aging? What the Science Says
NMN and NR do raise blood NAD+. But the science shows the benefits are real, limited, and work nothing like supplement ads claim. Here is what actually holds up.
Open →"NAD⁺ Supplementation for Anti-Aging and Wellness": Where the 2026 PRISMA Review Leaves the Evidence
113 studies. Clear biological activity, inconclusive clinical benefit. A close read of the 2026 PRISMA review: what NR/NMN actually do, what they don't, and what often gets left out of the conversation.
Open →Contagious Cell Death: How Ferroptosis and Pyroptosis Lock Aging into an Inflammatory Loop
Ferroptosis and pyroptosis are two forms of cell death that rupture and splash pro-inflammatory cargo onto neighboring cells. Four 2026 studies — spanning skin fibroblasts, brain microglia and neurons, and diabetic kidneys — trace the same self-amplifying loop and identify three brake points: HIF-1α, stem-cell-secreted TSG-6, and puerarin's control of caspase-1.
Open →The Mitochondrial Recycling Truck: Why Aging Cells Can't Clear Broken Power Plants — and Set Themselves on Fire
Mitophagy — the cell's recycling system for damaged mitochondria — slows with age, letting broken units pile up and leak bacterial-like mtDNA that triggers chronic inflammation. Four 2026 studies show restarting this pathway in rheumatoid arthritis and Alzheimer's models suppresses downstream inflammasome activation, while a fourth study reveals selective autophagy extends well beyond mitochondria.
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