How NAD+ depletion flips mitochondria from energy engines into aging accelerators: a 2025 npj review pinpoints why cellular power plants quit pulling their weight.

Picture a city. Every building needs electricity. When the power grid starts failing, you don't just lose the lights — hospitals shut down, water treatment stop

Seven longevity genes evolved over a billion years sit idle without NAD+. Imai and Guarente's classic npj review on why sirtuins need fuel to extend lifespan.

By 50 you have half the NAD+ you had at 20. Imai's NAD World 3.0 framework in npj Aging cracks the cellular supply chain behind mammalian aging and the pause button.

Your DNA takes over 10,000 oxidative hits per day. NLRP10 is the fire alarm that keeps that damage from cascading into cancer. Researchers just mapped exactly how it detects double-strand breaks — and what happens when it goes silent.