Grimoire

Your AI Has Access to Everything — and Understands Nothing

The $0.55 Research Session: How Splitting NotebookLM and Claude Cuts Token Costs 17x

Feeding 47 papers into Claude costs $9.59 per 5-round session. Using NotebookLM for retrieval and Claude for reasoning drops that to $0.55. The secret: not a single word of your papers ever enters Claude.

Telomeres Aren't Just a Life Clock: How They Stoke Inflammation and Drag Down Brainpower

Telomeres are usually cast as the cell's countdown timer that hits zero and you age. But two studies show they manage far more than time: shorten them, and immune cells' mitochondria misfire, inflammation ignites, and cognition takes a causally-linked hit. Telomeres, it turns out, move both inflammation and brainpower.

If Aging Had a Master Switch: Can SIRT1 Activators Rescue the Aging Brain?

The brain slows and dulls with age. Could a drug flip a single switch and turn that around? A 2026 review puts its bet on SIRT1, the NAD⁺-dependent enzyme whose depletion in the brain is tied to cognitive decline and dementia. Promising, but still far from a human prescription.

13 Attention Mechanisms Explained: How AI Decides What to Focus On

Your Cells Are Faking Oxygen Starvation: Three Truths About the NAD⁺ Collapse

You took NMN for three months and still look the same in the mirror. Why? Three landmark studies piece together how NAD⁺ collapses with age: how cells fake hypoxia, who eats your supplements, and whether topping NAD⁺ back up can truly rejuvenate old cells.