Long-form analysis at the intersection of AI and life sciences — all spells, sorted by time.
The immune cells designed to protect your joints become the ones destroying them. New research shows how immunosenescence starts in cartilage and spreads systemically — and why your knee pain is an early warning of full-body immune failure.
It's not laziness. Your cells are literally losing power. A 2025 Nature Aging review maps out how fast NAD+ disappears — and what you can do about it.
Why some run marathons at 70 while others need dialysis at 50: Nature Aging shows the same mitochondrial mutation triggers opposite fates in two kidney cell types.
How NAD+ depletion flips mitochondria from energy engines into aging accelerators: a 2025 npj review pinpoints why cellular power plants quit pulling their weight.
Seven longevity genes evolved over a billion years sit idle without NAD+. Imai and Guarente's classic npj review on why sirtuins need fuel to extend lifespan.