Long-form analysis at the intersection of AI and life sciences — all spells, sorted by time.
REV-ERBα is a circadian protein that works overnight to clear the molecular debris linked to Alzheimer's — and it runs on NAD+. When NAD+ drops with age, the overnight cleanup crew stops showing up. This is what that costs you.
Your DNA takes over 10,000 oxidative hits per day. NLRP10 is the fire alarm that keeps that damage from cascading into cancer. Researchers just mapped exactly how it detects double-strand breaks — and what happens when it goes silent.
Why some run marathons at 70 while others need dialysis at 50: Nature Aging shows the same mitochondrial mutation triggers opposite fates in two kidney cell types.
How NAD+ depletion flips mitochondria from energy engines into aging accelerators: a 2025 npj review pinpoints why cellular power plants quit pulling their weight.
By 50 you have half the NAD+ you had at 20. Imai's NAD World 3.0 framework in npj Aging cracks the cellular supply chain behind mammalian aging and the pause button.
Seven longevity genes evolved over a billion years sit idle without NAD+. Imai and Guarente's classic npj review on why sirtuins need fuel to extend lifespan.